Journal of Endocrinology and Reproduction

K. Sakthishree ¹, M. Selvaraj ¹, G. Vanithakumari ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore-641046, IN

Abstract

The effects of diclofenac sodium on the activities of the steroidogenic enzymes 3β-Phydroxy steroid dehydrogenase and 17β-Phydroxy steroid dehydrogenase as well as testosterone hormone titres were studied in albino rats, at a dosage of 300μg/kg. body weight for short, mid and long duration treatments. The effect of withdrawal of the drug for a month and supplementation with vitamin E were also studied.

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M. Selvaraj ¹, G. Vanithakumari ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore-641046, IN

Abstract

Non-steroidal anti-inflammatory drug, diclofenac sodium (Voveran) was injected intramuscularly at 1.5mgand3.0mg/kgbody weight respectively and vitamin E was administered orally at 4.0 mg/kg body weight for a period of 4 weeks to adult male albino rats. Low dose of diclofenac given for 4 weeks brought about marked reduction in the caudal tubular diameter. The infiltration of intra tubular connective tissue were pronounced.

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